The .375 Ruger is a powerful centerfire rifle cartridge introduced in 2007, designed to deliver classic .375-caliber dangerous-game performance from a standard-length rifle action. It is used for large and dangerous game worldwide.

The .375 Ruger was introduced in 2007 by Ruger and Hornady, designed to match or exceed the performance of the long-revered .375 H&H Magnum while fitting in a standard-length rifle action rather than the longer magnum action the older cartridge requires. The .375 caliber has a storied reputation as a versatile dangerous-game bore, and the .375 Ruger aimed to modernize and compact that capability. Ballistically the .375 Ruger drives heavy .375-caliber bullets at high velocity, delivering the high energy and deep penetration the .375 class is known for — performance long trusted for the largest and most dangerous game, including in Africa, as well as large North American game. Its efficient case allows that performance from a shorter, often lighter rifle. As with all cartridges in this power class, recoil is heavy, a tradeoff inherent to dangerous-game capability. It established a solid following among hunters wanting .375 H&H-class performance in a more compact, often more affordable package, with established rifle and ammunition support for its specialized role. Today the .375 Ruger is used for large and dangerous-game hunting and big-game hunting, with steady availability among rifles built for serious game. Its combination of classic .375 dangerous-game performance in a standard-length action is what defines its place among large-bore cartridges.

General information about this caliber — not a recommendation for this specific firearm.